|General information||Species distribution||Numeration assumed||Sequence conservation||3D conservation||Contacts with DNA|
The ETS domain is approximately 85-90 aa DNA-binding domain, that specifically interacts with sequences containing
the common core trinucleotide GGA. ETS domains contain three alpha-helixes and four-stranded
beta-sheets forming a winged helix-turn-helix (wHTH) topology.
The third alpha-helix is responsive to contact to the major groove of the DNA.
This domain is rich in positively-charged and aromatic residues.
Originally ETS domain was discovered in v-oncogene as part of a fusion protein gag-myb-ets expressed by a transforming retrovirus avian E26 (that is where the abbreviation ETS comes from) that induces a mixed erythroid/myeloid leukemia in chickens, and later shown to be transduced from a cellular gene.
Many of the ETS proteins have been shown to be transcription activators, ETS proteins have been implicated in regulation of gene expression during a variety of biological processes, including growth control, transformation, T-cell activation, and developmental programs in many organisms. Evidence is accumulating for a role for ETS family members in Drosophila development, Xenopus oocyte maturation, lymphocyte differentiation, and viral infectious cycles. ETS domain is also involved in protein-protein interactions with co-factors that help determine its biological activity.Most Ets family proteins are nuclear targets for activation of Ras-MAP kinase signaling pathway and some of them affect proliferation of cells by regulating the immediate early response genes and other growth-related genes.
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