ETS family


General information Species distribution Numeration assumed Sequence conservation 3D conservation Contacts with DNA

A typical ETS domain

General information

   The ETS domain is approximately 85-90 aa DNA-binding domain, that specifically interacts with sequences containing the common core trinucleotide GGA. ETS domains contain three alpha-helixes and four-stranded beta-sheets forming a winged helix-turn-helix (wHTH) topology. The third alpha-helix is responsive to contact to the major groove of the DNA. This domain is rich in positively-charged and aromatic residues.
   Originally ETS domain was discovered in v-oncogene as part of a fusion protein gag-myb-ets expressed by a transforming retrovirus avian E26 (that is where the abbreviation ETS comes from) that induces a mixed erythroid/myeloid leukemia in chickens, and later shown to be transduced from a cellular gene.
   Many of the ETS proteins have been shown to be transcription activators, ETS proteins have been implicated in regulation of gene expression during a variety of biological processes, including growth control, transformation, T-cell activation, and developmental programs in many organisms. Evidence is accumulating for a role for ETS family members in Drosophila development, Xenopus oocyte maturation, lymphocyte differentiation, and viral infectious cycles. ETS domain is also involved in protein-protein interactions with co-factors that help determine its biological activity.Most Ets family proteins are nuclear targets for activation of Ras-MAP kinase signaling pathway and some of them affect proliferation of cells by regulating the immediate early response genes and other growth-related genes.


References:
Wasylyk B, Hahn SL, Giovane A., The Ets family of transcription factors. Eur J Biochem. 1993 Jan 15;211(1-2):7-18.
Tsuneyuki Oikawa and Toshiyuki Yamada, Molecular biology of the Ets family of transcription factors. Gene, Volume 303 , 16 January 2003, Pages 11-34
© A.Grishin, A.Alexeevski, A.Karyagina, S.Spirin

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